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Génétique systématique



introduction

From1991to1997, ChinaZengBangzhe (Zengjie) publishedaseriesofpaperson "StructuralTheory-Pan-evolutionTheory", expoundingthestructuralintegrationofbiologicalsystems (intégration) andadjustmentofhomeostasis, Constructivehierarchicaltheory, andtheconceptsofsystemmedicine (1992,1995), systembiologicalengineering (SystemBiologicalEngineering, 1994) andsystemgenetics (1994), "andcoinedThetermandvocabularyof systemgenetics" putsforwardthedevelopmentviewofclassical, molecularandsystemgenetics.

Sponsoredthe1stInternationalSymposiumonGeneticallyModifiedAnimalsin1996, whichdiscussedthesystematictheoryofgeneself-organizationandspecificexpression, geneticsandbioengineering, andpublishedin2003and2008onthe19thand20thTheInternationalCongressofGeneticsandthe13thInternationalCongressofBiotechnologyin2008, etc., Usedthevocabularyofstructure, système, andpatterngeneticstodescribesystematicscientificmethods, computermodels, throughputbiology.Technologystudiestheresearchfieldof-etdes "génotype-expression" complexsystembetweenthegeneticstructureofbiologicalsystemandthemorphologicalschemaofbiologicalsystem, withcellsignaltransductionpathwayandgeneregulationnetworkasthecoretostudycellevolution, celldevelopment, cellpathology, andcellpharmacologyNon-linearsystemdynamicsthatoccurinthecell.

Développement international

En2003, Norwegianscientists (previouslycommunicatedwithZengBangzheabouttheconceptofgenetics) calledintegrativegeneticsandestablishedaresearchcenter.In2005, CambienF.andLaurenceT.publishedtheirviewsonsystemgeneticsinarteriosclerosisresearch.MorahanG., WilliamsRW.wasequivalentto2007 (EditedbyBockG., GoodeJ.) Onsystemgenetics.Willbecomethenextgenerationofgeneticsdevelopment.From2005to2008, internationalsystematicgeneticsresearchdevelopedrapidly.EuropeanandAmericancountriesestablishedmanysystematicgeneticsresearchcentersandlaboratories.In2008, theNationalInstitutesofHealth (NIH) establishedaspecialfundforsystematicgeneticsresearchontumors.TheConferenceonIntegrationandSystematicGeneticswasheldinCaliforniainMarch2008, andtheSymposiumonSystematicGeneticswasheldintheNetherlandsinOctober2009 .

Méthodes

La génétique des systèmes, à l'aide de la modélisation informatique, les équations mathématiques des systèmes, la nanobiotechnologie à haut débit, les expériences de puces microfluidiques et d'autres méthodes pour étudier la logique structurelle du génome, l'évolution de la structure du génome, la stabilité du génome et la génération de modèles biologiques et morphologiques sur la dynamique des systèmes non linéaires.

SystemGeneticsanditsapplicationtechnology-biologie synthétique, includingthedevelopmentoftechnologiessuchasbioreactorsandcellcomputers, followingMendelianclassicalgenetics, WatsonandKlickMoleculargenetics, aswellasgeneticbreeding, cellhybridization, geneticallymodifiedorganismsandothertechnologies, willbecomeanewtrendinthedevelopmentofgeneticsandgeneticengineeringinthe21stcentury.Itwillrevealtheevolutionmechanismofbiologicalsystemsandstudythestructure, functionandevolutionofthegenome.Self-organizingsystem, exploringthecomplexsystemof fromgenometoorganism "génotype-phénotype", involvingtheregulationofgenesystemssuchasmedicalgeneticsandmedicalpsychology, researchonsignaltransductionnetworks, aswellasfortumors, geneticdiseases, mentalillnesses, le vieillissement, etc.Thediagnosisofdiseaseoccurrence, le dépistage des médicaments et l'industrie pharmaceutique ont ouvert de nouvelles voies.

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